HPVs are naked, circular, dsDNA viruses with an icosahedral capsid. Size: 52-55 nm.
The importance of HPVs in the medical field grew in the 1970s, when their connection to cervical cancer was discovered.
HPV infection causes papillomas (benign growths).
Some HPVs that cause genital warts, increase the risk of anogenital, oral and cervical cancers.
The genome of HPV is organized into coding and noncoding regions. The outside capsid is made out of a protein called L1.
There are over a 100 types of HPVs identified so far, based on the nucleotide sequence of their outer capsid protein L1.
The HPV infection targets the basal layer of epithelial cells.
The importance of HPVs in the medical field grew in the 1970s, when their connection to cervical cancer was discovered.
HPV infection causes papillomas (benign growths).
Some HPVs that cause genital warts, increase the risk of anogenital, oral and cervical cancers.
The genome of HPV is organized into coding and noncoding regions. The outside capsid is made out of a protein called L1.
There are over a 100 types of HPVs identified so far, based on the nucleotide sequence of their outer capsid protein L1.
The HPV infection targets the basal layer of epithelial cells.
Most HPV infections are cleared by the human immune response, but the virus has mechanisms to evade that, especially in immunocompromised patients.
Life Cycle of HPV
Not fully understood.
The virus's life cycle and the differentiation process of the host's cell are related.
The virus attach and enter a stem cell in the basal layer, to reach the nucleus and establish its genome as extra-chromosomal plasmids
Replication of the viral genome occurs in the S-phase.
After mitosis, daughter cells migrate away from the basal layer, to start differentiation. HPV gene products maintain cells in cell cycle and block nuclei degradation.
Scientist have not been able to successfully replicate the virus in substantial amount in the laboratory, but there has been progress since the use of different tissue culture models.
Not fully understood.
The virus's life cycle and the differentiation process of the host's cell are related.
The virus attach and enter a stem cell in the basal layer, to reach the nucleus and establish its genome as extra-chromosomal plasmids
Replication of the viral genome occurs in the S-phase.
After mitosis, daughter cells migrate away from the basal layer, to start differentiation. HPV gene products maintain cells in cell cycle and block nuclei degradation.
Scientist have not been able to successfully replicate the virus in substantial amount in the laboratory, but there has been progress since the use of different tissue culture models.